Diamond currently has five experimental stations dedicated to structural biology as well as the on-site Membrane Protein Laboratory, recently developed in partnership with Imperial College London and funded by the Wellcome Trust.Since Diamond opened in 2007, over 500 protein structures have been solved there including enzymes associated with hypertension, tuberculosis and HIV.Since its foundation in 1907, Imperial's contributions to society have included the discovery of penicillin, the development of holography and the foundations of fibre optics .
In 2007, Imperial College London and Imperial College Healthcare NHS Trust formed the UK's first Academic Health Science Centre.
This unique partnership aims to improve the quality of life of patients and populations by taking new discoveries and translating them into new therapies as quickly as possible.
Advances in structural biology have accelerated greatly as a result of access to the synchrotron facilities that have been developed around the world in the past 25 years.
Researchers in the UK are at the forefront of this work and Diamond Light Source provides cutting edge facilities for protein structure determination.
By showing exactly how histamines bind to the H1 receptor at the molecular level, we can design and develop much more targeted treatments.” The research was technically challenging because membrane proteins are notoriously difficult to crystallise – a step that is vital in solving protein structures using a synchrotron.
The proteins were grown in cells at Kyoto University in Japan, then processed cell material was flown to Professor Raymond Stevens at The Scripps Research Institute in La Jolla, California, who leads the GPCR Network of the National Institute of General Medical Sciences' Protein Structure Initiative, and has developed powerful techniques to analyse membrane proteins and crystallise G-protein coupled receptors (GPCRs) funded by the National Institutes of Health Common Fund.
The tree is a source of many compounds having high medicinal value.
In gastrointestinal tract, histamine H2 receptors have key role in histamine-stimulated gastric acid secretion.
An international team of scientists using Diamond Light Source, the UK’s national synchrotron facility, has successfully solved the complex 3D structure of the human Histamine H1 receptor protein.